01
Resolve the target
Point Biologix at any protein biologic by name or PDB id. The platform fetches the structure and sets up screening — the same workflow runs unchanged across targets.
Agentic discovery for biologic formulation
Discovering the polymers that keep biologics stable.
Biologix is an agentic platform that explores polymer excipients for protein biologics — pairing physics-grounded screening with agent-backed retrosynthesis and regulatory checks, keeping a human in the loop at every step.
Built on peer-reviewed research
Physics-grounded · OpenMM & Packmol
Agent-backed retrosynthesis
Human-in-the-loop checkpoints
How it works
One discovery loop, run start to finish.
Each iteration moves from literature to candidate polymers to simulation, then closes synthesis feasibility and safety before a human reviews the results and steers the next round.
02
Mine & propose
It reads the relevant literature, then generates candidate polymer excipients as validated repeat-unit structures ready for simulation.
03
Screen with physics
Each candidate is packed around the target and energy-minimized with OpenMM and Packmol, scoring how strongly the polymer interacts with the biologic.
04
Close the loop
Agent-backed retrosynthesis traces each promising candidate to purchasable precursors, while ADMET and regulatory rules screen for safety and compliance.
05
Human checkpoint
Every iteration pauses for review. You see the ranked candidates, their routes and their flags, then steer where the next round goes.
Why it matters
The cold chain limits who biologics can reach.
Many biologics must stay refrigerated from factory to patient. That dependence puts them out of reach in settings without reliable cold storage.
A thermally protective matrix polymer could change that calculus — but the space of possible excipients is vast, and whether a candidate can actually be synthesized is rarely checked at discovery time.
Biologix runs discovery and synthesis feasibility together, with regulatory and safety screening built into every iteration — so the candidates that surface are ones a human can meaningfully act on.
The platform
What Biologix brings to the loop.
Biologic-agnostic
Run the same loop on insulin, an antibody, an enzyme or a peptide — resolved from a name or PDB identifier.
Physics-grounded screening
Interaction energies from OpenMM and Packmol, not guesswork, rank how a polymer shell binds the target.
Agent-backed retrosynthesis
Candidate routes are traced to purchasable building blocks through a four-tier precursor registry.
Safety & compliance
Monomer ADMET plus FDA / EMA / GRAS excipient rules screen candidates before they reach you.
Human-in-the-loop
A mandatory checkpoint each iteration keeps a scientist in control of every decision.
Full provenance
Every candidate, route and check is logged with its source, so results are auditable end to end.
Request a demo
See Biologix on your target.
Tell us about the biologic you're formulating and what you'd like to explore. We'll be in touch to arrange a walkthrough.